S. P. BESSMAN
In the latter part of the nineteenth century an operation to shunt portal blood around the liver was developed by Eck. The advantage of using this operation to study liver function in the experimental animal was recognized by a number of investigators. By 1893, it was known that a dog, operated upon in this manner, could no longer tolerate a high protein diet.1 A characteristic syndrome developed after a short time. The dog became irritable, then would walk with a staggering gait, lifting its feet high and slapping them down on the floor. As forced meat feeding continued, the animal
BESSMAN SP. THE RÔLE OF AMMONIA IN CLINICAL SYNDROMES. Ann Intern Med. ;44:1037–1043. doi: 10.7326/0003-4819-44-5-1037
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Published: Ann Intern Med. 1956;44(5):1037-1043.
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