CHRIST ARAVANIS, M.D.; ALDO A. LUISADA, M.D., F.A.C.P.
Treatment of angina pectoris still is a difficult problem of great practical importance. Even though rapidly acting drugs like nitroglycerin may give temporary relief, any drug causing a lasting subjective improvement and an increase of working capacity is of great interest to the practitioner.
It has been stated that choline theophyllinate causes a marked and lasting improvement in cases with coronary heart disease and anginal pain, and that such improvement is far greater than that obtained with aminophylline. Moreover, the disadvantages encountered with aminophylline (gastric intolerance, gradually decreasing effect) were not found with the choline derivate. A sharp denial of
ARAVANIS C, LUISADA AA. RESULTS OF TREATMENT OF ANGINA PECTORIS WITH CHOLINE THEOPHYLLINATE BY THE DOUBLE-BLIND METHOD1. Ann Intern Med. 1956;44:1111–1122. doi: 10.7326/0003-4819-44-6-1111
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Published: Ann Intern Med. 1956;44(6):1111-1122.
Cardiology, Coronary Heart Disease.
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