JOSEPH E. SOKAL, M.D.; GILBERT H. GLASER, M.D.
Nervous system involvement occurs in 10 to 15% of cases of Hodgkin's disease.1 In the great majority this consists of compression of the spinal cord or of nerve roots by tumor in vertebrae extending extradurally, or by metastases to spinal meninges. Much rarer are intracranial lesions. These usually consist of involvement of the meninges around the base of the brain, or of impingement on cranial nerves at the foramina of the skull. Invasion of brain substance by Hodgkin's granuloma is extremely rare.2 Generalized convulsions are occasionally described in Hodgkin's disease. They usually occur in the terminal stage of the disease
SOKAL JE, GLASER GH. AN UNUSUAL NEUROLOGIC SYNDROME IN HODGKIN'S DISEASE1. Ann Intern Med. ;44:1250–1259. doi: 10.7326/0003-4819-44-6-1250
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Published: Ann Intern Med. 1956;44(6):1250-1259.
Hematology/Oncology, Leukemia/Lymphoma, Neurology.
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