STUART W. COSGRIFF, M.D.
Anticoagulant therapy with the coumarin and indandione derivatives has been made less hazardous by the demonstration that Vitamin K1 and Vitamin K1 oxide1-5 produce a prompt reversal of excessive hypoprothrombinemia. Intravenous Vitamin K1 in dosage varying from 50 to 500 mg. of the oil-soluble emulsion will effect the prompt return of an elevated prothrombin time approximately to normal within 12 hours in most patients, frequently accompanied by cessation of bleeding when a hemorrhagic complication is present.
The emulsion of Vitamin K1, originally prepared for intravenous administration, has been reported also to be effective by mouth.6-9 Hanson7 found that the prothrombin
COSGRIFF SW. THE EFFECTIVENESS OF AN ORAL VITAMIN K1 IN CONTROLLING EXCESSIVE HYPOPROTHROMBINEMIA DURING ANTICOAGULANT THERAPY1. Ann Intern Med. ;45:14–22. doi: 10.7326/0003-4819-45-1-14
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Published: Ann Intern Med. 1956;45(1):14-22.
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