STUART W. COSGRIFF, M.D.
Anticoagulant therapy with the coumarin and indandione derivatives has been made less hazardous by the demonstration that Vitamin K1 and Vitamin K1 oxide1-5 produce a prompt reversal of excessive hypoprothrombinemia. Intravenous Vitamin K1 in dosage varying from 50 to 500 mg. of the oil-soluble emulsion will effect the prompt return of an elevated prothrombin time approximately to normal within 12 hours in most patients, frequently accompanied by cessation of bleeding when a hemorrhagic complication is present.
The emulsion of Vitamin K1, originally prepared for intravenous administration, has been reported also to be effective by mouth.6-9 Hanson7 found that the prothrombin
COSGRIFF SW. THE EFFECTIVENESS OF AN ORAL VITAMIN K1 IN CONTROLLING EXCESSIVE HYPOPROTHROMBINEMIA DURING ANTICOAGULANT THERAPY(THE EFFECTIVENESS OF AN ORAL VITAMIN K1 IN CONTROLLING EXCESSIVE HYPOPROTHROMBINEMIA DURING ANTICOAGULANT THERAPY*). Ann Intern Med. 1956;45:14–22. doi: 10.7326/0003-4819-45-1-14
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Published: Ann Intern Med. 1956;45(1):14-22.
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