C. HOUGIE, M.B., B.S., L.R.C.P., M.R.C.S. (Eng.)
It is well known that chronic lymphatic leukemia may run a long and practically asymptomatic course. The classic picture of splenomegaly, lymphadenopathy, anemia and a very high leukocyte count is probably only a late phase in the natural history, but it is this stage of the disease that has received the most study. The pathologic processes at the inception of a disease are always the most interesting, yet there are few clinicopathologic data on chronic lymphatic leukemia in its early stages. This is probably because the opportunity to observe the course of leukemia before the disease has caused symptoms is
HOUGIE C. THE EARLY DIAGNOSIS AND NATURAL HISTORY OF CHRONIC LYMPHATIC LEUKEMIA1. Ann Intern Med. ;45:39–55. doi: 10.7326/0003-4819-45-1-39
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Published: Ann Intern Med. 1956;45(1):39-55.
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