IRWIN D. STEIN, M.D., F.A.C.P.
A pressing need in the management of the chronic occlusive arterial diseases is an effective oral vasodilator to control the common presenting complaint of intermittent claudication. Many drugs and procedures have been tried but found wanting, some because of undesirable side-effects and difficulty in administration, others because they improved circulation in skin areas and did little to relieve muscle ischemia.
Some years ago, while investigating the effects of the intra-arterial injection of adrenalin upon blood flow in the forearm,1 we were struck by the marked dilation it produced in muscle even in minute concentration. These doses proved to be constrictor,
STEIN ID. ARLIDIN: A CLINICAL EVALUATION OF A PERIPHERAL VASODILATOR WITH SELECTIVE ACTION ON MUSCLE VESSELS12. Ann Intern Med. ;45:185–190. doi: 10.7326/0003-4819-45-2-185
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Published: Ann Intern Med. 1956;45(2):185-190.
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