MICHAEL B. SHIMKIN, M.D., F.A.C.P.; MATTHEW H. GRISWOLD, M.D.; SIDNEY J. CUTLER, M.A.
The most obvious manifestation of cancer is that it kills. In 1878 Winiwarter1 published a detailed analysis of Billroth's surgical experience in cancer. Approximately 10% of 548 patients were alive and were stated to be clinically free of cancer following treatment. The follow-up period for many of the patients was less than three years. Nevertheless, the demonstration that the fatal course of cancer could be interrupted in some patients by treatment had great influence and served as an important stimulus to the development of surgery in cancer. It was also taken as evidence for the concept of the unifocal origin
SHIMKIN MB, GRISWOLD MH, CUTLER SJ. SURVIVAL IN UNTREATED AND TREATED CANCER1. Ann Intern Med. ;45:255–267. doi: 10.7326/0003-4819-45-2-255
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Published: Ann Intern Med. 1956;45(2):255-267.
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