MARTIN G. NETSKY, M.D.; JAMES MACD. WATSON, M.D.
The history of development of signs and symptoms is used in the differential diagnosis between neoplastic and vascular disease of the brain. The diagnosis of a brain tumor first depended on recognition of the triad—headache, nausea and vomiting, and papilledema. This was later realized to be nonspecific evidence of increased intracranial pressure, and hence often the end-stage of the course of a cerebral neoplasm. In 1933 Bailey1 said that the presence of tumor should and can be diagnosed before the appearance of the triad. He gave as the cardinal symptom of tumor of the nervous system a history of nonfebrile,
NETSKY MG, WATSON JM. THE NATURAL HISTORY OF INTRACRANIAL NEOPLASMS1. Ann Intern Med. ;45:275–284. doi: 10.7326/0003-4819-45-2-275
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Published: Ann Intern Med. 1956;45(2):275-284.
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