J. R. D. BAYNE, M.D.; P. W. DARBY, M.B., B.S.
The value of the sugar content of the cerebrospinal fluid in cases of meningeal involvement by metastatic carcinoma is not widely appreciated. Metastatic involvement of the central nervous system is not uncommon, occurring in 2 to 6% of most reported series of cancer. Lesse and Netsky,1 however, found central nervous system involvement in 35% of a series of cases in which the brain was examined. Many of these cases were asymptomatic, particularly where metastasis was limited to the dura, but in 10% central nervous system signs were the first to appear. Headache and signs of meningeal irritation were surprisingly uncommon;
BAYNE JRD, DARBY PW. LOW CEREBROSPINAL FLUID SUGAR IN MENINGEAL CARCINOMATOSIS1. Ann Intern Med. ;45:285–288. doi: 10.7326/0003-4819-45-2-285
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Published: Ann Intern Med. 1956;45(2):285-288.
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