ESTHER FINCHER HAYS, M.D.; THOMAS C. SCANLAN, M.D.; RALPH L. ENGLE JR., M.D.
The subject of this case report lived for nearly five years after the diagnosis of acute leukemia was made. The course of the disease was unique in that it contained three distinct clinical remissions, each initiated by treatment with a-methopterin. The course and therapy are depicted in figure 1.
A 32 year old German Jewish housewife was admitted to the New York Hospital in June, 1949, with a history of fatigability, fever, sore throat and swollen neck glands for two months.
Physical examination revealed fever and pallor. Petechiae, bleeding hypertrophied gums and small cervical lymph nodes were also
HAYS EF, SCANLAN TC, ENGLE RL. MULTIPLE REMISSIONS IN AN ADULT WITH ACUTE LEUKEMIA TREATED PRINCIPALLY WITH A-METHOPTERIN1. Ann Intern Med. ;45:306–311. doi: 10.7326/0003-4819-45-2-306
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Published: Ann Intern Med. 1956;45(2):306-311.
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