C. J. WATSON, M.D., Ph.D., F.A.C.P.
It was the great contribution of Hijmans van den Bergh and his associates, Snapper and Muller, to apply the Ehrlich-Proscher diazo reaction for bilirubin to the bilirubin of blood serum and body fluids in qualitative and quantitative fashion.1, 2 This work, which appeared during and just at the end of World War I, gave a new impetus to the study of jaundice, liver disease and the anemias. In the subsequent years an extensive literature has accumulated on the subject, from both fundamental and clinical points of view. There is universal agreement on the specificity and general value of the total
WATSON CJ. THE IMPORTANCE OF THE FRACTIONAL SERUM BILIRUBIN DETERMINATION IN CLINICAL MEDICINE1. Ann Intern Med. 1956;45:351–368. doi: 10.7326/0003-4819-45-3-351
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Published: Ann Intern Med. 1956;45(3):351-368.
Biliary Disorders, Education and Training, Gastroenterology/Hepatology, Hospital Medicine, Liver Disease.
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