MAURICE M. BEST, M.D., F.A.C.P.; CHARLES H. DUNCAN, M.D.
The reports by Peterson that the addition of soybean sterols to experimental diets of chicks appeared to inhibit the absorption of cholesterol1 and to effect a decreased incidence of atherosclerosis2 have stimulated study of the effects of ingestion of various plant sterols.
The presence in higher plants of sterols (phytosterols) which are closely related to cholesterol has long been recognized. The most widely distributed of the phytosterols are the sitosterols, of which there are at least five. Gamma sitosterol is the principal sterol of soybean oil, and presumably the active component of the sterol mixture employed by Peterson. Studies in
BEST MM, DUNCAN CH. MODIFICATION OF ABNORMAL SERUM LIPID PATTERNS IN ATHEROSCLEROSIS BY ADMINISTRATION OF SITOSTEROL(MODIFICATION OF ABNORMAL SERUM LIPID PATTERNS IN ATHEROSCLEROSIS BY ADMINISTRATION OF SITOSTEROL*). Ann Intern Med. 1956;45:614–622. doi: 10.7326/0003-4819-45-4-614
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Published: Ann Intern Med. 1956;45(4):614-622.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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