GEORGE L. JACKSON, M.D.; DAVID A. SMITH, M.D.
Clinical observations of the enhanced effectiveness of narcotics given with chlorpromazine have been reported by several investigators.1, 2, 3, 4, 5, 6 These reports suggest that one may anticipate more complete and longer lasting relief from pain as a result of concomitant administration of these agents. Because of its potential value in reducing the amount of analgesic required, it seemed advisable to subject this observation to controlled clinical testing.
Accordingly, the following experiments were designed to determine:
1. Whether the method of testing would yield results comparable to those reported by Beecher and his associates relative to the analgesic properties
JACKSON GL, SMITH DA. ANALGESIC PROPERTIES OF MIXTURES OF CHLORPROMAZINE WITH MORPHINE AND MEPERIDINE1. Ann Intern Med. ;45:640–652. doi: 10.7326/0003-4819-45-4-640
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Published: Ann Intern Med. 1956;45(4):640-652.
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