ROY C. GUMPEL, M.D.; JOSE D. CARBALLO, M.D.
The disease familial adenomatosis has long been recognized, the first description being variously accredited to Menzel1 in 1721 and Virchow2 in 1863. It is characterized by a diffuse adenomatous involvement of the colon, a heredofamilial incidence and a close relationship to cancer of the large bowel. It is a distinct disease entity and is to be differentiated from postinflammatory polyposis and nonfamilial discrete polyps of the colon.
Multiple sessile or pedunculated proliferations of the mucous membrane of the entire colon are found. Often there is a predilection for the terminal bowel and, rarely, the involvement is segmental. The stomach and
GUMPEL RC, CARBALLO JD. A NEW CONCEPT OF FAMILIAL ADENOMATOSIS1. Ann Intern Med. ;45:1045–1058. doi: 10.7326/0003-4819-45-6-1045
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Published: Ann Intern Med. 1956;45(6):1045-1058.
Colorectal Cancer, Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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