WILLIAM CARL EBELING, M.D.; JOAN W. LITTLE
Despite the widespread application and popularity of the cytologic diagnosis of cancer, there has been relatively little interest in utilizing this technic for the demonstration of carcinomatous lesions of the large bowel. The apparent reason for this lack of emphasis has been the obvious difficulty encountered in the collection of cells. Certainly the time-honored clinical methods used in the detection of colonic carcinoma have left much room for improvement, especially in cases where the tumor has been located beyond the reach of the sigmoidoscope.
The previously reported work is scant. Significant contributions by others will be mentioned briefly. Loeb
EBELING WC, LITTLE JW. THE DEMONSTRATION OF MALIGNANT CELLS EXFOLIATED FROM THE PROXIMAL COLON1. Ann Intern Med. ;46:21–29. doi: 10.7326/0003-4819-46-1-21
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Published: Ann Intern Med. 1957;46(1):21-29.
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