MICHAEL C. KOZONIS, M.D.; IRFAN GUREVIN, M.D.
The C-reactive protein test is a highly sensitive test for the presence of acute inflammation. The capsule of the pneumococcus bacterium contains a specific polysaccharide called C polysaccharide, which behaves as a specific antigen. If one studies the sera of patients with pneumonitis of pneumococcal origin, an antibody for this C polysaccharide can be demonstrated. The antibody is a protein and has been named C-reactive protein.
In 1930 Tillet and Francis1 demonstrated for the first time the presence of the above substance in a patient with pneumococcal pneumonitis. Later they observed that this substance was found only in sera of
KOZONIS MC, GUREVIN I. THE VALUE OF THE C-REACTIVE PROTEIN DETERMINATION IN CORONARY ARTERY DISEASE1. Ann Intern Med. ;46:79–85. doi: 10.7326/0003-4819-46-1-79
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Published: Ann Intern Med. 1957;46(1):79-85.
Cardiology, Coronary Heart Disease, Coronary Risk Factors.
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