CHARLES H. SLOCUMB, M.D.; HOWARD F. POLLEY, M.D., F.A.C.P.; L. EMMERSON WARD, M.D.; PHILIP S. HENCH, M.D., F.A.C.P.
In the relatively brief period of six years of intensive clinical and biochemical investigations, the great potency of cortisone, corticotropin and related adrenocortical hormonal preparations has been demonstrated.1 However, knowledge as to how the various effects of these hormones are mediated and how they may be used therapeutically to best advantage and with greatest safety is still incomplete.
The therapeutic use of cortisone or its analogues or corticotropin must still be based on careful consideration of both the anticipated benefits and the potential disadvantages of the hormone for each disease and each patient. These considerations become especially important when long-term
SLOCUMB CH, POLLEY HF, WARD LE, HENCH PS. DIAGNOSIS, TREATMENT AND PREVENTION OF CHRONIC HYPERCORTISONISM IN PATIENTS WITH RHEUMATOID ARTHRITIS1. Ann Intern Med. 1957;46:86–101. doi: 10.7326/0003-4819-46-1-86
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Published: Ann Intern Med. 1957;46(1):86-101.
Adrenal Disorders, Endocrine and Metabolism, Rheumatoid Arthritis, Rheumatology.
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