BYRON A. NICHOL; S. M. DOZIER; THOMAS W. MATTINGLY
This case report concerns a patient who presented a diagnostic problem of cardiomegaly and myocardial failure of unknown etiology and in whom the outstanding pathologic finding at autopsy was primary systemic amyloidosis with marked cardiac involvement. An additional finding of great interest was the presence of numerous Russell bodies in the bone marrow. For previously reported cases (approximately 100) and reviews of the literature of primary systemic amyloidosis,1-14 we found no report of similar bone marrow findings though Snapper, Turner and Moscovitz15 have reported Russell bodies in the bone marrow in atypical amyloidosis accompanying multiple myeloma. Morphologically, amyloidosis associated with
NICHOL BA, DOZIER SM, MATTINGLY TW. PRIMARY SYSTEMIC AMYLOIDOSIS WITH CARDIAC INVOLVEMENT AND WITH RUSSELL BODIES IN BONE MARROW1. Ann Intern Med. ;46:156–168. doi: 10.7326/0003-4819-46-1-156
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Published: Ann Intern Med. 1957;46(1):156-168.
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