ALEXANDER M. MINNO, M.D.; JAMES A. ROGERS, M.D.
Ochronosis is an extremely rare disorder but, when present, is quite disabling. We have recently had an opportunity to observe a patient with alkaptonuria and secondary ochronosis. It has been noted that alkaptonuria may be present for many years before the signs and symptoms of ochronosis become pronounced. If alkaptonuria is detected early, the onset of the so-called alkaptonuric or ochronotic osteoarthritis may perhaps be delayed.
In 1866 Virchow recorded the first case of ochronosis, describing the pigmentation of cartilage and other tissues. More than 200 cases of alkaptonuria and 100 cases of ochronosis have since been reported. Several groups
ALEXANDER M. MINNO, JAMES A. ROGERS. OCHRONOSIS: REPORT OF A CASE(OCHRONOSIS: REPORT OF A CASE*). Ann Intern Med. 1957;46:179–183. doi: 10.7326/0003-4819-46-1-179
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Published: Ann Intern Med. 1957;46(1):179-183.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Osteoarthritis.
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