J. RICHARD JOHNSON, M.D.; NANCY E. FURSTENBERG, M.D.; ROY PATTERSON, M.D.; HENRY K. SCHOCH, M.D.; WINTHROP N. DAVEY, M.D.
The proposition that corticotropin and the adrenal steroids are worthy and often vital adjuncts to the antimicrobial therapy of certain infections has been strongly defended by some1, 2 and just as strongly refuted by others.3, 4 In this regard, it must be accepted that these hormones (if used alone) do reduce the resistance of many species of hosts to a wide variety of infections.3 Experimental animal studies of combined hormonal and antimicrobial therapy, however, show little consistency as to results, even in the same species of animals.5
When using such combinations of drugs in clinical situations, the proponents of
JOHNSON JR, FURSTENBERG NE, PATTERSON R, SCHOCH HK, DAVEY WN. CORTICOTROPIN AND ADRENAL STEROIDS AS ADJUNCTS TO THE TREATMENT OF TUBERCULOUS MENINGITIS(CORTICOTROPIN AND ADRENAL STEROIDS AS ADJUNCTS TO THE TREATMENT OF TUBERCULOUS MENINGITIS*). Ann Intern Med. 1957;46:316–331. doi: 10.7326/0003-4819-46-2-316
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Published: Ann Intern Med. 1957;46(2):316-331.
Adrenal Disorders, CNS Infections, Endocrine and Metabolism, Infectious Disease, Mycobacterial Infections.
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