F. J. BORGES, M.D.; S. P. BESSMAN, M.D.
The intestinal tract has long been considered the source of powerful chemical agents. This philosophy was formalized by Metchnikoff, and gave rise to the theory of autointoxication prevalent in the early decades of the twentieth century. Within the last few years workers in many fields in many countries have seen their researches converge upon a potent substance which might well be one of the powerful amines envisioned by Metchnikoff.
For the last 100 years it has been known to physiologists that the vasoconstrictor properties of the blood increase when blood clots. This constituted a serious problem for the investigators who
BORGES FJ, BESSMAN SP. SEROTONIN. Ann Intern Med. ;46:425–430. doi: 10.7326/0003-4819-46-2-425
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Published: Ann Intern Med. 1957;46(2):425-430.
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