IRVIN L. SCHWEITZER
Paroxysmal cold hemoglobinuria is a rare hemolytic disorder of which there are two distinct varieties. The syphilitic form is caused by a specific hemolysin which becomes fixed to erythrocytes when the patient is chilled and causes hemolysis when the patient is subsequently warmed. It is almost invariably associated with an inactive phase of late congenital or acquired syphilis. The non-syphilitic form is caused by a high titer of cold agglutinins and is frequently associated with vascular disorders such as the Raynaud syndrome. The following is a case of syphilitic paroxysmal cold hemoglobinuria with three aspects of special interest: (1) it
SCHWEITZER IL. SYPHILITIC PAROXYSMAL COLD HEMOGLOBINURIA1. Ann Intern Med. ;46:590–594. doi: 10.7326/0003-4819-46-3-590
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Published: Ann Intern Med. 1957;46(3):590-594.
Hematology/Oncology, Red Cell Disorders.
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