MANUEL J. ROWEN, M.D., F.A.C.P.
Leukemia as a clinical entity has been recognized for many years. It is identified by various combinations of adenopathy, hepatosplenomegaly, anemia and varied bleeding tendencies, as well as by other factors such as infection and necrosis. When the disease is full-blown clinically the bone marrow findings should be conclusive. Frequently they are not performed because of the obvious clinical picture and the appearance of the peripheral blood. According to Wintrobe,1 "Hyperplasia is usually diffuse and widespread throughout the marrow spaces"; however, it is conceivable that it may not involve all of the marrow spaces at all stages of the
ROWEN MJ. PROBLEM IN THE DIAGNOSIS OF LEUKEMIA1. Ann Intern Med. ;46:907–914. doi: 10.7326/0003-4819-46-5-907
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Published: Ann Intern Med. 1957;46(5):907-914.
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