JOE E. HOLOUBEK, F.A.C.P., M.D.; O. C. THOMAS, M.D.; JACOB SEGURA, M.D.
A new type of tranquilizing drug, Miltown (2-methyl-2-n-propyl-1,3, propanediol dicarbamate),1 has been recently introduced for the treatment of anxiety, nervousness and tension states. The incidence of toxic reactions has been minimal. Selling reported adverse reactions in only three out of 187 patients treated with a total of 54,100 tablets. One patient had two fainting spells and a temperature of 102° F. two and one-half hours after taking two tablets. One hundred fifty milligrams of Pyribenzamine orally were given every four hours and in two days the temperature cleared and the edema subsided. Another patient developed urticaria four days after treatment
HOLOUBEK JE, THOMAS OC, SEGURA J. TOXIC REACTION TO 2-METHYL-2-N-PROPYL-1,3, PROPANEDIOL DICARBAMATE (MILTOWN AND EQUANIL)1. Ann Intern Med. ;46:1002–1004. doi: 10.7326/0003-4819-46-5-1002
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Published: Ann Intern Med. 1957;46(5):1002-1004.
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