EDWARD E. WOLDMAN, M.D., F.A.C.P.; DAVID FISHMAN, M.D.
Chlorpromazine (Thorazine) is being widely used in the treatment of various psychiatric disorders,1 the nausea and vomiting of diverse etiology,2 intractable hiccups,3 and as an analgesic.4 The sedative, tranquilizing and calming properties of the drug also make it useful as an adjunct in the treatment of a variety of conditions.
Numerous side-effects have been noted following the administration of chlorpromazine, but most of them are usually not severe enough to warrant discontinuing the drug therapy. However, one of the most disturbing side-effects of this therapy is jaundice, which has been reported quite frequently during this last year. The laboratory observations
WOLDMAN EE, FISHMAN D. INTRAHEPATIC OBSTRUCTIVE JAUNDICE FOLLOWING THE ADMINISTRATION OF 75 MG. OF CHLORPROMAZINE1. Ann Intern Med. ;47:332–338. doi: 10.7326/0003-4819-47-2-332
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Published: Ann Intern Med. 1957;47(2):332-338.
Biliary Disorders, Gastroenterology/Hepatology.
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