EMANUEL APPELBAUM, M.D., F.A.C.P.; SINOVIJ SHTOKALKO, M.D.
The therapy of cryptococcosis remains a challenge, particularly when there is involvement of the central nervous system. A wide variety of drugs and agents has been used to combat this disease, presumably with successful results in rare instances, but usually without any effect upon the course of the infection. In recent years the antifungal antibiotics, Acti-dione and nystatin, have attracted particular attention. There have been several reports of recovery following the use of Acti-dione. However, after reviewing all the known cases treated with this drug, Carton1 concludes that Acti-dione is not very effective against central nervous system cryptococcosis. As far
APPELBAUM E, SHTOKALKO S. CRYPTOCOCCUS MENINGITIS ARRESTED WITH AMPHOTERICIN B1. Ann Intern Med. ;47:346–351. doi: 10.7326/0003-4819-47-2-346
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Published: Ann Intern Med. 1957;47(2):346-351.
CNS Infections, Infectious Disease, Neurology.
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