H. CHARLES WALKER JR., M.D.; MICHAEL F. KOSZALKA, M.D., F.A.C.P.
Since the introduction of bromsulphalein as a test for liver function by Rosenthal and White1, 2 approximately 30 years ago, it has come to be considered a safe, innocuous and invaluable diagnostic clinical procedure.3-7 Only rare toxic reactions without serious consequences have occurred.8-13 The purpose of this paper is to report a fatal reaction to bromsulphalein (sulfobromophthalein, U.S.P.; phenoltetrabromphthalein-disodium sulfonate). To our knowledge, this is the first such case to be documented.
A 58 year old married Indian laborer was first hospitalized from April 19, 1955, to May 16, 1955. His complaint at that time was intermittent acute
WALKER HC, KOSZALKA MF. FATAL BROMSULPHALEIN REACTION1. Ann Intern Med. ;47:362–366. doi: 10.7326/0003-4819-47-2-362
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Published: Ann Intern Med. 1957;47(2):362-366.
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