IRVIN C. PLOUGH; LAURENCE H. KYLE, M.D.
The most frequent cause of hyperparathyroidism is an adenoma of a parathyroid gland. The course of events leading to adenoma formation in the parathyroids, as in other tissues of the body, is unknown. In some organs, conditioning factors can be identified which seem to predispose to the formation of such tumors. For example, in the thyroid gland, iodine deficiency produces hyperplasia and nodule formation, and on occasion functionally active adenomas appear. The possibility has been considered that a similar train of events sometimes precedes the appearance of a parathyroid adenoma.1 In conditions such as rickets, osteomalacia and renal insufficiency, where
PLOUGH IC, KYLE LH. PANCREATIC INSUFFICIENCY AND HYPERPARATHYROIDISM1. Ann Intern Med. ;47:590–598. doi: 10.7326/0003-4819-47-3-590
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Published: Ann Intern Med. 1957;47(3):590-598.
Endocrine and Metabolism, Gastroenterology/Hepatology, Pancreatic Disease, Parathyroid Disorders.
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