BERNARD M. SIEGEL, M.D.; IRVING A. FRIEDMAN, M.D.; SAMUEL KESSLER, M.D.; STEVEN O. SCHWARTZ, M.D., F.A.C.P.
Clinicians have become increasingly alert to a syndrome characterized by the association of hemolytic anemia, thrombocytopenia and neurologic manifestations, first described by Moschcowitz1 and recently extensively reviewed by Singer.2 The number of cases reported has increased in proportion to growing awareness.
The term "thrombotic thrombocytopenic purpura" is in popular use for this syndrome,3 although a somewhat more descriptive name, "thrombohemolytic thrombocytopenic purpura," has also been proposed.4
In the reported cases the course is always said to have been fulminating and downward from the time of the clinical appearance of the diagnostic triad; however, reëxamination of the tissues of patients who
BERNARD M. SIEGEL, IRVING A. FRIEDMAN, SAMUEL KESSLER, STEVEN O. SCHWARTZ. THROMBOHEMOLYTIC THROMBOCYTOPENIC PURPURA AND LUPUS ERYTHEMATOSUS(THROMBOHEMOLYTIC THROMBOCYTOPENIC PURPURA AND LUPUS ERYTHEMATOSUS*). Ann Intern Med. 1957;47:1022–1029. doi: 10.7326/0003-4819-47-5-1022
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Published: Ann Intern Med. 1957;47(5):1022-1029.
Coagulopathies, Hematology/Oncology, Lupus Erythematosus, Platelet Disorders, Rheumatology.
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