ROGER H. UNGER, M.D.
The convenience of the standard two-hour oral glucose tolerance test has led to its widespread use as a means of detecting early derangements of carbohydrate metabolism in individuals with normal fasting blood sugars.
In adequately prepared subjects, failure of the blood sugar to return to 100 mg.% ("true glucose") within two hours after an oral glucose load is commonly interpreted as evidence of diabetes mellitus or "prediabetes."1 Despite this, the diagnostic specificity for diabetes mellitus of modest elevations in two-hour blood sugar level has never been established. The possibility exists, therefore, that normal persons are being mislabeled as diabetics by
UNGER RH. THE STANDARD TWO-HOUR ORAL GLUCOSE TOLERANCE TEST IN THE DIAGNOSIS OF DIABETES MELLITUS IN SUBJECTS WITHOUT FASTING HYPERGLYCEMIA(THE STANDARD TWO-HOUR ORAL GLUCOSE TOLERANCE TEST IN THE DIAGNOSIS OF DIABETES MELLITUS IN SUBJECTS WITHOUT FASTING HYPERGLYCEMIA*). Ann Intern Med. 1957;47:1138–1153. doi: 10.7326/0003-4819-47-6-1138
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Published: Ann Intern Med. 1957;47(6):1138-1153.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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