JOHN A. SHEEDY; WENDELL F. LIENHARD
Among the various endocrine deficiency states, hypothyroidism has been one of the most frequently diagnosed entities. The striking signs and symptoms of myxedema are generally quite well known to physicians, and diagnosis has been regarded as relatively easy, even without laboratory studies. The possibility that there might be patients with only a few of the classic signs and symptoms of myxedema prompted much speculation and study. Plummer1 has been credited with the recognition in 1917 of a group termed "euthyroid hypo-metabolism." It was noted that these patients often complained of lethargy, easy fatigability, nervousness, irritability, emotional instability, sensitivity to cold,
SHEEDY JA, LIENHARD WF. COMPARISON OF CLINICAL AND LABORATORY FINDINGS IN ALLEGED AND TRUE HYPOTHYROIDISM1. Ann Intern Med. ;47:1184–1201. doi: 10.7326/0003-4819-47-6-1184
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Published: Ann Intern Med. 1957;47(6):1184-1201.
Endocrine and Metabolism, Thyroid Disorders.
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