BENJAMIN MANCHESTER, F.A.C.P.
Experience in the last decade has established the therapeutic efficacy of anticoagulants. The successful prevention of thrombo-embolic complications, as well as the reduced mortality in myocardial infarction, has led to the continuation of antithrombotic therapy following recovery from an acute attack. The fear of recurrence, with increased mortality and disability, haunts the individual. The continuation of therapy proved effective in the acute phase, gives the patient reassurance and optimism. Prolonged anticoagulation therapy offers a physiologic approach toward prevention of subsequent myocardial infarction.
This report presents the experience of continuous long-term anticoagulant therapy observed from one to 10 years in 712
MANCHESTER B. THE VALUE OF CONTINUOUS (1 TO 10 YEARS) LONG-TERM ANTICOAGULANT THERAPY1. Ann Intern Med. ;47:1202–1209. doi: 10.7326/0003-4819-47-6-1202
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Published: Ann Intern Med. 1957;47(6):1202-1209.
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