GEORGE B. GORDON, M.D.; ELIAS GECHMAN, M.D.; ROBERT ROSENGARTEN, M.D.; ANTHONY P. NEPTUNE, M.D.
Among the many clinicopathologic entities in which the fundamental lesion consists of widespread necrotizing angiitis and granuloma formation, Wegener's granulomatosis can be recognized as a distinctive syndrome. Its leading features are necrotizing granulomatous lesions of the nasal passages, sinuses and respiratory tract, generalized arteritis, and focal glomerulitis with terminal uremia. Klinger1 reported the first case in 1931, and Wegener2 described the features which distinguish this syndrome from other forms of angiitis. Extensive clinical3 and pathologic4 studies have formulated the criteria which make possible the clinical recognition of this rare disorder.
The etiology of Wegener's granulomatosis is not known. Necrotizing angiitis,
GORDON GB, GECHMAN E, ROSENGARTEN R, NEPTUNE AP. WEGENER'S GRANULOMATOSIS1. Ann Intern Med. 1957;47:1260–1266. doi: 10.7326/0003-4819-47-6-1260
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Published: Ann Intern Med. 1957;47(6):1260-1266.
Autoimmune Kidney Disease, Interstitial Lung Disease, Nephrology, Pulmonary/Critical Care, Rheumatology.
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