PAUL BUNN, M.D., F.A.C.P.; ALDONA BALTCH, M.D.; WINIFRED OSBORNE, B.S.; LEONARD CANARILI, B.S.
Unlike the situation in virtually every other human infection caused by cocci, there is now no clearly described best antimicrobial therapy for penicillin-resistant staphylococcal infections. This report is concerned with in vitro studies upon staphylococcal growth as inhibited by eight antimicrobial agents, used singly and in various combinations, and with observations made in the management of 60 cases of serious staphylococcal infections in adults.
Prior to 1941 three of four patients with staphylococcal infection complicated by bacteremia died, with the course of disease mostly uninfluenced by antiserum and sulfonamides.1, 2 From 1942 until 1946, with the use of penicillin, the
BUNN P, BALTCH A, OSBORNE W, CANARILI L. STAPHYLOCOCCI: ON THE UBIQUITOUS NATURE OF HUMAN INFECTIONS AND THEIR CONTROL BY ANTIMICROBIAL AGENTS, SINGLY OR IN COMBINATION12. Ann Intern Med. ;48:102–113. doi: 10.7326/0003-4819-48-1-102
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Published: Ann Intern Med. 1958;48(1):102-113.
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