EDWARD G. SAYERS, M.D., F.R.A.C.P., F.R.C.P., F.A.C.P. (Hon.)
Acute myocarditis is a common complication of diphtheria and is said to occur in from 10 to 25% of cases and to be responsible for from 50 to 60% of the deaths from this disease.
Pathologic changes consist of fatty and hyaline changes in heart muscle, sometimes associated with necrotic changes or toxic myolysis in muscle fibers. Interstitial changes also occur, consisting of edema and infiltration with lymphocytes, neutrophilic and eosinophilic leukocytes, monocytes and fibroblasts.
It seems rather extraordinary that, despite the clinical severity of many cases of acute diphtheritic myocarditis and the widespread pathologic damage reported, it is seldom
SAYERS EG. DIPHTHERITIC MYOCARDITIS WITH PERMANENT HEART DAMAGE(DIPHTHERITIC MYOCARDITIS WITH PERMANENT HEART DAMAGE*). Ann Intern Med. 1958;48:146–157. doi: 10.7326/0003-4819-48-1-146
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Published: Ann Intern Med. 1958;48(1):146-157.
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