MILTON S. SACKS, M.D.
Recent studies from a variety of sources would seem to establish the existence of a humoral substance capable of stimulating erythropoiesis and, under certain experimental conditions, even producing a polycythemic state. In contradistinction to certain essential metabolites such as iron, folic acid, and cyanocobalamin which may be looked upon as necessary building blocks for erythrocyte maturation, the plasma erythropoietic stimulating factor seems to be fundamentally concerned in the regulatory mechanism which maintains the remarkable constancy of the red cell mass in health, which stimulates erythropoiesis after hemorrhage or after exposure to an atmosphere of reduced oxygen tension, which inhibits the
SACKS MS. ERYTHROPOIETIN. Ann Intern Med. ;48:207–212. doi: 10.7326/0003-4819-48-1-207
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Published: Ann Intern Med. 1958;48(1):207-212.
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