STANLEY BERGEN JR., M.D.; FRED J. SCHILLING, M.D., F.A.C.P.
During the last few years sporadic cases of afibrinogenemia and hypofibrinogenemia have been appearing in the literature. Diminished levels or total lack of fibrinogen has occasionally been noted as a congenital abnormality,6, 17 but usually this disturbance in hemostasis is acquired. The earliest recorded cases were reported in shock, or in hemorrhagic,1, 24 traumatic24 or anaphylactic response to antigens.24 A decrease of plasma fibrinogen levels has been noted in cases of severe liver necrosis from phenobarbital and methyl alcohol34 and chloroform.24 More recently, afibrinogenemia has been reported following pulmonary operations,15 in preëclampsia, the first day of menstruation,35 amniotic fluid embolus,18
BERGEN S, SCHILLING FJ. CIRCULATING FIBRINOLYSIN IN A CASE OF PROSTATIC CARCINOMA WITH BONY METASTASES1. Ann Intern Med. ;48:389–398. doi: 10.7326/0003-4819-48-2-389
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Published: Ann Intern Med. 1958;48(2):389-398.
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