A. STEPHEN CLOSE, M.D.; YOSHIRA TAIRA, M.D.; DAVID A. CLEVELAND, M.D., F.A.C.S.
Extramedullary hematopoiesis, or myeloid metaplasia, is a frequently encountered condition, occurring usually in association with certain types of anemia. It is particularly prone to occur with anemia due to myelophthisis or myelosclerosis, and is usually thought of as a compensatory mechanism whereby extramedullary tissue attempts to compensate for a deficiency of the marrow. However, extramedullary hematopoiesis is found often in autopsy material from cases in which there is no detectable bone marrow deficiency. Cholesterolemia and arteriosclerosis (experimentally), and various toxins and infections, are also known to be capable of initiating extramedullary hematopoiesis.9, 12 Regardless of the cause or causes, in
CLOSE AS, TAIRA Y, CLEVELAND DA. SPINAL CORD COMPRESSION DUE TO EXTRAMEDULLARY HEMATOPOIESIS1. Ann Intern Med. ;48:421–427. doi: 10.7326/0003-4819-48-2-421
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Published: Ann Intern Med. 1958;48(2):421-427.
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