WILLIAM DAMESHEK, M.D., F.A.C.P.
Systemic (disseminated) lupus erythematosus has been known for at least 50 years, but its exact nature and the pathogenetic mechanisms bringing it about are almost as obscure now as they were when the disease was first described. Considered a rarity for the first three decades of the present century, its incidence seems to be increasing steadily, although whether this is actually so or the result of better recognition is difficult to state.
Systemic lupus must still be classed as a complex disorder of obscure origin. Even its histopathology has been in doubt, often in the hands of the same
DAMESHEK W. SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPLEX AUTO-IMMUNE DISORDER?12. Ann Intern Med. ;48:707–730. doi: 10.7326/0003-4819-48-4-707
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Published: Ann Intern Med. 1958;48(4):707-730.
Lupus Erythematosus, Rheumatology.
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