IRWIN H. KRAKOFF, M.D.; ROBERT D. SULLIVAN, M.D.
In advanced and nonresectable neoplastic disease certain chemical agents have been found to have some effect in slowing the growth or in producing temporary regression of the tumor tissue. Nearly all of the agents which are capable of producing such effects, when administered systemically, also have toxic effects on the bone marrow, liver or other organs. Host toxicity is the limiting factor in dosage, and prevents the use of sufficient amounts of drug to produce drastic effects on the tumor.
Klopp et al.1-4 reported that in patients with inoperable cancer in whom the principal manifestations of the disease were largely
KRAKOFF IH, SULLIVAN RD. INTRA-ARTERIAL NITROGEN MUSTARD IN THE TREATMENT OF PELVIC CANCER12. Ann Intern Med. ;48:839–850. doi: 10.7326/0003-4819-48-4-839
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Published: Ann Intern Med. 1958;48(4):839-850.
Hematology/Oncology, Hospital Medicine.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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