HARRY GLENCHUR, M.D.; HORACE H. ZINNEMAN, M.D., F.A.C.P.; DAVID R. BRIGGS, Ph.D.
In 1944 Waldenström presented his paper on "Incipient Myelomatosis or 'Essential' Hyperglobulinemia with Fibrinogenopenia—A New Syndrome?" In it he described three patients with refractory anemia and bleeding tendency whose sera exhibited a very high viscosity. Waldenström speculated that a special globulin fraction was the cause of the increased viscosity, and by ultracentrifugation studies he was able to demonstrate that the sera of two of these patients contained macroglobulins with molecular weights of over 1,000,000.1 Since then other reports have been published, mostly from Europe, of single cases or small series, with a similar clinical picture and the presence of macroglobulins
GLENCHUR H, ZINNEMAN HH, BRIGGS DR. MACROGLOBULINEMIA: REPORT OF TWO CASES1. Ann Intern Med. ;48:1055–1069. doi: 10.7326/0003-4819-48-5-1055
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Published: Ann Intern Med. 1958;48(5):1055-1069.
Hematology/Oncology, Hospital Medicine, Infectious Disease, Leukemia/Lymphoma, Multi-Organ Failure and Sepsis.
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