R. M. BECKER, M.D., F.A.C.P.
A previous report1 described the in vivo action of penicillinase on circulating penicillin in guinea pigs and human subjects without reactions. The following is a report of the clinical effectiveness of penicillinase in humans with penicillin reactions.
Penicillinase2 is an enzyme specific for its substrate penicillin. Its inactivating action against penicillin has been utilized for years in the clinical laboratory in bacteriologic media to inhibit penicillin in body fluids to be cultured. Penicillinase can be obtained from several strains of bacteria, including staphylococci and Escherichia coli. Commercially it is produced in greatest abundance from cultures of Bacillus cereus, strain NRRL-B
BECKER RM. A NEW CONCEPT IN THE TREATMENT OF PENICILLIN REACTIONS: USE OF PENICILLINASE12. Ann Intern Med. ;48:1228–1242. doi: 10.7326/0003-4819-48-6-1228
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Published: Ann Intern Med. 1958;48(6):1228-1242.
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