MARTIN E. GORDON, M.D.; EDWARD SHANBROM, M.D.
In 1933 Henrik Sjögren1 amplified Gougerot's original description2 of a syndrome consisting of dryness of the mucous membranes and the eyes, with parotid glandular enlargement in menopausal women. Since then several excellent reviews3, 4, 5 have emphasized that the disease is of a diverse nature, with such manifestations as polyarthritis, dryness of the vulva and vagina, diminished perspiration, Raynaud's phenomena, scleroderma, hypochromic anemia, alopecia, achylia gastrica and an altered glucose tolerance.
Infrequent attempts6, 7, 8 have been made to study the pathogenesis of this condition by noting histopathologic changes occurring in accessible organs. The following report is an evaluation of
MARTIN E. GORDON, EDWARD SHANBROM. THE SYSTEMIC MANIFESTATIONS OF SJÖGREN'S SYNDROME: REPORT OF GLANDULAR FUNCTION WITH HISTOLOGIC, BACTERIAL AND VIRAL STUDIES(THE SYSTEMIC MANIFESTATIONS OF SJÖGREN'S SYNDROME: REPORT OF GLANDULAR FUNCTION WITH HISTOLOGIC, BACTERIAL AND VIRAL STUDIES*). Ann Intern Med. 1958;48:1342–1359. doi: 10.7326/0003-4819-48-6-1342
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Published: Ann Intern Med. 1958;48(6):1342-1359.
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