J. WILLIAM OBERMAN, M.D.; ENID F. GILBERT, M.D.
Following the original report of Schoenbach et al.1 of the successful therapy of a case of systemic North American blastomycosis treated with the aromatic diamidine, stilbamidine, numerous publications have attested to the efficacy of this drug in the treatment of blastomycosis and other mycotic infections.2-10 Due, however, to the high incidence of trigeminal neuropathy in patients receiving stilbamidine, it is frequently necessary to discontinue the drug before a full therapeutic effect is attained.2, 5, 11-13 More recently, other reports of the successful use of a stilbamidine derivative, 2-hydroxystilbamidine, in the therapy of these diseases have appeared.5, 10, 14-17 No serious
OBERMAN JW, GILBERT EF. THE TOXICITY OF 2-HYDROXYSTILBAMIDINE: PROBABLE FATAL TOXIC REACTION DURING TREATMENT OF BLASTOMYCOSIS1. Ann Intern Med. ;48:1401–1414. doi: 10.7326/0003-4819-48-6-1401
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Published: Ann Intern Med. 1958;48(6):1401-1414.
Emergency Medicine, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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