KOUICHI R. TANAKA, M.D.; GEORGE O. CLIFFORD, M.D.
Although hemoglobin electrophoresis is being performed in numerous centers throughout the world, patients with homozygous hemoglobin C disease are encountered infrequently.1 Hemoglobin C trait has been found to be present in 2 to 3% of American Negroes,2, 3 and the incidence of homozygous hemoglobin C disease has been calculated to be one in 6,000 Negroes.1 In the course of a study of hemoglobinopathies during the period of 1953 to 1956, three patients with this hemoglobin pattern have been encountered. Each of these patients was a diagnostic problem until hemoglobin electrophoresis was performed, which revealed only the presence of hemoglobin C.
TANAKA KR, CLIFFORD GO. HOMOZYGOUS HEMOGLOBIN C DISEASE: REPORT OF THREE CASES1. Ann Intern Med. 1958;49:30–42. doi: 10.7326/0003-4819-49-1-30
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Published: Ann Intern Med. 1958;49(1):30-42.
Hematology/Oncology, Red Cell Disorders.
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