MILTON N. LURIA, M.D.; SAMUEL P. ASPER JR., M.D., F.A.C.P.
Of the many clinical features of Graves' disease, alterations in the nails are probably the least frequently recognized. The late Dr. Henry S. Plummer, of the Mayo Clinic, was apparently the first to call attention to trophic changes of the fingernails in hyperthyroidism. He described longitudinal striations and flattening of the nail which, when pronounced, produce a "scoop shovel" appearance. A more striking change in the nails, however, which Dr. Plummer also described and the one with which this communication is concerned, is the condition known as onycholysis. This clinical sign has been considered pathognomonic of Graves' disease for almost
LURIA MN, ASPER SP. ONYCHOLYSIS IN HYPERTHYROIDISM1. Ann Intern Med. ;49:102–108. doi: 10.7326/0003-4819-49-1-102
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Published: Ann Intern Med. 1958;49(1):102-108.
Endocrine and Metabolism, Thyroid Disorders.
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