LEO J. CASS, M.D.; WILLEM S. FREDERIK, M.D.
In recent years significant advances have been made in the development of forms of medication which will more effectively provide the patient with the total daily prescribed dose. These newer forms of medication eliminate the necessity of taking doses of medicine at two-, three- or four-hour intervals. The common goal in the development of sustained release preparations is to provide a medication that will be clinically effective with a maximum of one or two oral doses in a 24-hour period. A sustained release preparation is one that will yield predictable amounts of the active component over an extended period
CASS LJ, FREDERIK WS. THE CLINICAL EVALUATION OF SUSTAINED RELEASE ANTITUSSIVES1. Ann Intern Med. ;49:151–160. doi: 10.7326/0003-4819-49-1-151
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Published: Ann Intern Med. 1958;49(1):151-160.
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