ARTHUR BERNSTEIN, M.D., F.A.C.P.; DAVID BRONSKY, M.D.; ALVIN DUBIN, M.S.
Uric acid stones comprise 4 to 6%1, 2 of all renal calculus disease. Treatment by surgical and dietary measures, by alkalinization of the urine and with salicylates has not been satisfactory. Such stones occur frequently in patients with gout. Probenecid (Benemid), a potent uricosuric agent, may effect a reversal of the clinical course of gout.3, 4 That it may also be highly effective in the treatment of recurrent uric acid stones in patients without symptomatic gout can be inferred by a consideration of the following case history.
A 64 year old white man was observed on January 2,
BERNSTEIN A, BRONSKY D, DUBIN A. SUCCESSFUL TREATMENT OF RECURRENT URIC ACID RENAL CALCULI WITH PROBENECID (BENEMID)(SUCCESSFUL TREATMENT OF RECURRENT URIC ACID RENAL CALCULI WITH PROBENECID (BENEMID)*). Ann Intern Med. 1958;49:203–207. doi: 10.7326/0003-4819-49-1-203
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Published: Ann Intern Med. 1958;49(1):203-207.
Gout, Nephrolithiasis, Nephrology, Rheumatology, Urological Disorders.
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