CLIFFORD W. GURNEY, M.D.; LEON O. JACOBSON, M.D., F.A.C.P.; EUGENE GOLDWASSER, Ph.D.
Until recently it was generally agreed that low oxygen tension in the bone marrow constituted a direct stimulus for red cell production. This view was challenged by many investigators whose studies demonstrated that the rate of erythropoiesis, both in vivo1, 2 and in marrow cultures,3, 4 was independent of changes in oxygen tension. Clearly an alternate hypothesis was needed.
In 1906 Carnot and Deflandre described the erythropoietic-stimulating properties of serum of anemic rabbits by injecting this serum into normal rabbits, thereby obtaining increased reticulocyte and hemoglobin values in the animals that received the anemic serum.5 This experimental procedure was employed
GURNEY CW, JACOBSON LO, GOLDWASSER E. THE PHYSIOLOGIC AND CLINICAL SIGNIFICANCE OF ERYTHROPOIETIN(THE PHYSIOLOGIC AND CLINICAL SIGNIFICANCE OF ERYTHROPOIETIN*). Ann Intern Med. 1958;49:363–370. doi: 10.7326/0003-4819-49-2-363
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Published: Ann Intern Med. 1958;49(2):363-370.
Hematology/Oncology, Hospital Medicine, Nephrology, Red Cell Disorders, Rheumatology.
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