VERNON KNIGHT, M.D., F.A.C.P.; ARTHUR C. WHITE, M.D.; MARGARET P. MARTIN, Ph.D.
An understanding of the role of drug resistance in current problems with staphylococcal infections will depend in part upon knowledge of the way in which antimicrobial therapy causes drug-resistant staphylococci to develop and persist in hospital patients. Observations in this laboratory suggest that these effects are produced by rather specific mechanisms, and a description of them is the purpose of this report.
Hospital patients who are staphylococcal carriers are an essential part of the chain of events leading to hospital cross-infections with drug-resistant staphylococci, for it is by the treatment of these carriers that drug-resistant staphylococci are
KNIGHT V, WHITE AC, MARTIN MP. THE EFFECT OF ANTIMICROBIAL DRUGS ON THE STAPHYLOCOCCAL FLORA OF HOSPITAL PATIENTS12. Ann Intern Med. 1958;49:536–543. doi: 10.7326/0003-4819-49-3-536
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Published: Ann Intern Med. 1958;49(3):536-543.
Hospital Medicine, Infectious Disease.
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